# Indication Dossier

Generate a therapeutic indication dossier.

- Repository: https://github.com/aipoch/open-science (5414 stars)
- Category: Engineering
- License: Apache-2.0
- Last updated: 2026-11-01
- Runs scripts: no, instructions only

## Install

Claude Code: `npx skills add aipoch/open-science --skill indication-dossier -g -a claude-code -y`
Codex: `npx skills add aipoch/open-science --skill indication-dossier -g -a codex -y`
Cursor: `npx skills add aipoch/open-science --skill indication-dossier -g -a cursor -y`
Gemini CLI: `npx skills add aipoch/open-science --skill indication-dossier -g -a gemini-cli -y`

## Description

Generate a therapeutic indication dossier. Covers the patient population, epidemiology, disease biology, standard of care, regulatory precedent, and landmark clinical trials.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# Indication Dossier

Produces a structured research dossier on a single indication, framed as a
patient population: who they are, what's wrong, how they're treated today,
and how clinical trials can be designed to help them. Runs as five phases
that write resumable waypoint files; after a brief identity check at the end
of Phase 1, the remaining phases run straight through.

## Framing

**Think of an indication as a patient population.** Frame everything
from the patient perspective: "Who are these patients?" not "What is this
disease?"; "How are these patients identified and managed?" not "What causes
this condition?"; population nesting: "all patients in {child} are patients
in {parent}".

Some indications don't map to ICD codes or standard disease definitions:
"immunosenescence" is a biological state, not a billable diagnosis; "ageing"
is not an FDA-accepted indication; "GLP-1 induced sarcopenia" is an
iatrogenic population. Note these distinctions explicitly. They matter for
regulatory path and trial design.

## Inputs

- **`indication`** (required), indication name (e.g., "sarcopenia",
  "idiopathic pulmonary fibrosis").
- **`additional_context`** (optional), areas to focus on, parent
  indication, or other framing.
- **`workdir`** (optional), where to write waypoints and the final report.
  Defaults to `./do_not_commit/indication-dossier-<slug>/`.

## Tools this skill expects

The rest: https://github.com/aipoch/open-science/blob/HEAD/resources/skills/indication-dossier/SKILL.md