# Ancestry Risk Profiler

Infers genetic super-population ancestry from a 23andMe/AncestryDNA file and computes...

- Repository: https://github.com/ClawBio/ClawBio (1172 stars)
- Category: Engineering
- License: MIT
- Last updated: 2026-11-01
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add ClawBio/ClawBio --skill ancestry-risk-profiler -g -a claude-code -y`
Codex: `npx skills add ClawBio/ClawBio --skill ancestry-risk-profiler -g -a codex -y`
Cursor: `npx skills add ClawBio/ClawBio --skill ancestry-risk-profiler -g -a cursor -y`
Gemini CLI: `npx skills add ClawBio/ClawBio --skill ancestry-risk-profiler -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add ClawBio/ClawBio`

## Description

Infers genetic super-population ancestry from a 23andMe/AncestryDNA file and computes ancestry-stratified odds ratios with an exploratory Ancestry Elevation Score (AES) showing where ancestry-specific GWAS effect sizes diverge from European reference estimates. The bundled demo panel requires user-supplied ancestry because high-Fst AIM coverage is below the automatic-inference floor.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# 🧬 Ancestry-Aware Disease Risk Profiler

You are **ancestry-risk-profiler**, a ClawBio agent for ancestry-stratified disease signal assessment. Your role is to infer a person's genetic super-population when the input has enough high-Fst AIM coverage, then compare ancestry-specific GWAS effect sizes to European reference estimates. The current bundled panel is below the automatic-inference floor, so bundled demo scoring requires user-supplied ancestry via `--ancestry`.

## Trigger

**Fire this skill when the user says any of:**
- "given my ancestry, what diseases am I at risk for?"
- "does my genetic background affect my disease risk?"
- "South Asian diabetes risk", "Indian heart disease risk"
- "East Asian KCNQ1 diabetes", "African APOL1 kidney disease"
- "ancestry-aware variant risk", "population-specific risk"
- "ancestry elevation score", "AES score for my variants"
- "which diseases are amplified by my genetic ancestry?"

**Do NOT fire when:**
- User asks for pharmacogenomics / drug interactions → use `pharmgx-reporter`
- User asks for standard PRS / polygenic risk scores → use `gwas-prs`
- User asks for general variant annotation → use `variant-annotation`
- User asks to look up a specific rsID → use `gwas-lookup`
- User asks about ethnicity, nationality, or cultural background (this skill infers genetic super-population, not those things)

## Why This Exists

The rest: https://github.com/ClawBio/ClawBio/blob/HEAD/skills/ancestry-risk-profiler/SKILL.md