# Claw Methylation Cycle

Methylation cycle analysis, enzymatic activity profiles, Net Methylation Capacity, BH4...

- Repository: https://github.com/ClawBio/ClawBio (1172 stars)
- Category: Engineering
- License: MIT
- Last updated: 2026-11-01
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add ClawBio/ClawBio --skill claw-methylation-cycle -g -a claude-code -y`
Codex: `npx skills add ClawBio/ClawBio --skill claw-methylation-cycle -g -a codex -y`
Cursor: `npx skills add ClawBio/ClawBio --skill claw-methylation-cycle -g -a cursor -y`
Gemini CLI: `npx skills add ClawBio/ClawBio --skill claw-methylation-cycle -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add ClawBio/ClawBio`

## Description

Methylation cycle analysis, enzymatic activity profiles, Net Methylation Capacity, BH4 axis estimates, compound heterozygosity detection from SNP genotype data.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# claw-methylation-cycle

Methylation cycle analysis skill for ClawBio. Produces enzymatic activity
profiles, Net Methylation Capacity (NMC), BH4 axis estimates, compound
heterozygosity detection, and clinician-review genotype findings from raw
SNP genotype data.

---

## Trigger

**Fire this skill when:**

- The user asks about methylation, MTHFR variants, folate cycle, or
  homocysteine risk from a genotype file.
- A raw SNP file (23andMe / ADNTRO / Ancestry format) is provided and the
  clinical question involves methylation, BH4, dopamine/serotonin synthesis
  capacity, or neurodevelopmental contexts (ADHD, depression, anxiety).
- The upstream workflow (PharmGx Reporter, NutriGx Advisor) has flagged
  MTHFR or MTRR and the clinician needs the full methylation panel.
- Keywords present: `methylation`, `MTHFR`, `BH4`, `folate cycle`,
  `metilación`, `ciclo de metilación`, `homocysteine`, `5-MTHF`,
  `methylcobalamin`, `neurotransmitter synthesis`, `dopamine upstream`.

**Do NOT fire this skill when:**

- The question is purely about folic acid supplementation without a genotype file.
- The user is asking about MTHFR in the context of thrombophilia/clotting
  only, use PharmGx Reporter for warfarin/anticoagulation questions.
- Only N-GENE polygenic risk data is available (no raw SNP file), this skill
  requires genotype-level input; PRS percentiles are not sufficient.
- The SNP file format is VCF, FASTQ, BAM, or PLINK binary, these require
  preprocessing before this skill can run.
- The clinical question is exclusively pharmacogenomic (CYP enzymes), use
  PharmGx Reporter instead.

---

## Workflow

1. **Receive input**, Accept either a raw genotype file path or a pre-parsed
   `snp_dict`. If a file is provided, call `parse_genotype_file()` to extract
   the rsID → genotype mapping.

The rest: https://github.com/ClawBio/ClawBio/blob/HEAD/skills/claw-methylation-cycle/SKILL.md