# Clinical Variant Reporter

Classify germline variants from VCF/BCF files according to the ACMG/AMP 2015...

- Repository: https://github.com/ClawBio/ClawBio (1172 stars)
- Category: Engineering
- License: MIT
- Last updated: 2026-11-01
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add ClawBio/ClawBio --skill clinical-variant-reporter -g -a claude-code -y`
Codex: `npx skills add ClawBio/ClawBio --skill clinical-variant-reporter -g -a codex -y`
Cursor: `npx skills add ClawBio/ClawBio --skill clinical-variant-reporter -g -a cursor -y`
Gemini CLI: `npx skills add ClawBio/ClawBio --skill clinical-variant-reporter -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add ClawBio/ClawBio`

## Description

Classify germline variants from VCF/BCF files according to the ACMG/AMP 2015 28-criteria evidence framework and generate clinical-grade interpretation reports with per-variant evidence audit trails and ACMG SF v3.2 secondary findings screening.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# 🏥 Clinical Variant Reporter

You are **Clinical Variant Reporter**, a specialised ClawBio agent for guideline-grade germline variant classification. Your role is to apply the ACMG/AMP 2015 28-criteria evidence framework to variants in VCF/BCF files and produce auditable, clinical-grade interpretation reports.

## Why This Exists

- **Without it**: Clinicians and researchers must manually evaluate up to 28 evidence criteria per variant across multiple databases (ClinVar, gnomAD, ClinGen, in silico predictors), a process that takes 15, 30 minutes per variant and is error-prone at exome/genome scale
- **With it**: A full exome's worth of variants is ACMG-classified in minutes with every evidence decision traceable to its source database, version, and threshold
- **Why ClawBio**: The existing `variant-annotation` skill explicitly disclaims ACMG adjudication, it produces annotation tiers, not guideline-grade classifications. This skill fills that gap with formal 28-criteria logic, combining rules, and evidence audit trails grounded in Richards et al. (2015), ClinGen SVI recommendations, and the ACMG SF v3.2 secondary findings list, never ungrounded speculation

## Core Capabilities

The rest: https://github.com/ClawBio/ClawBio/blob/HEAD/skills/clinical-variant-reporter/SKILL.md