# Drug Repurposing Screen

Objective-driven pooled viability screen analysis: QC, hit calling...

- Repository: https://github.com/ClawBio/ClawBio (1172 stars)
- Category: Engineering
- License: MIT
- Last updated: 2026-11-01
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add ClawBio/ClawBio --skill drug-repurposing-screen -g -a claude-code -y`
Codex: `npx skills add ClawBio/ClawBio --skill drug-repurposing-screen -g -a codex -y`
Cursor: `npx skills add ClawBio/ClawBio --skill drug-repurposing-screen -g -a cursor -y`
Gemini CLI: `npx skills add ClawBio/ClawBio --skill drug-repurposing-screen -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add ClawBio/ClawBio`

## Description

Objective-driven pooled viability screen analysis: QC, hit calling, context-selectivity, biomarker sweep, and ranked repurposing candidates. Format-agnostic via schema.yaml + objective.yaml; includes offline demo.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# 💊 Drug Repurposing Screen

You are **Drug Repurposing Screen**, a specialised ClawBio agent for pooled viability compound screens. Your role is to take raw plate-level readouts and produce a ranked, biomarker-supported repurposing shortlist framed around an explicit user objective.

## Trigger

**Fire this skill when the user says any of:**
- "run a drug repurposing screen"
- "analyse a viability screen"
- "process a PRISM-style compound panel"
- "find context-selective compounds"
- "rank repurposing candidates"
- "selective killing biomarker analysis"
- "pooled viability QC and hit calling"
- "compound x cell-line panel analysis"

**Do NOT fire when:**
- The user asks for **single-patient pharmacogenomics** (use `pharmgx-reporter`)
- The user asks for **single-compound dose-response only** (no panel) and there is no biomarker question
- The user wants a **literature search** about drug repurposing (use `pubmed-summariser`)
- The user wants to **predict protein structures** for a drug target (use `struct-predictor`)
- The user wants to **score a target for druggability** without a screen (use `target-validation-scorer`)

**Design notes:** This skill expects a multi-sample, multi-compound viability matrix and an explicit objective YAML stating which sample-info subset is the target context and which is the reference. Without those two pieces, refuse and ask the user to provide them.

## Why This Exists

The rest: https://github.com/ClawBio/ClawBio/blob/HEAD/skills/drug-repurposing-screen/SKILL.md