# Fine Mapping

Statistical fine-mapping of GWAS loci using SuSiE, SuSiE-inf, and Approximate Bayes...

- Repository: https://github.com/ClawBio/ClawBio (1172 stars)
- Category: Engineering
- License: MIT
- Last updated: 2026-11-01
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add ClawBio/ClawBio --skill fine-mapping -g -a claude-code -y`
Codex: `npx skills add ClawBio/ClawBio --skill fine-mapping -g -a codex -y`
Cursor: `npx skills add ClawBio/ClawBio --skill fine-mapping -g -a cursor -y`
Gemini CLI: `npx skills add ClawBio/ClawBio --skill fine-mapping -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add ClawBio/ClawBio`

## Description

Statistical fine-mapping of GWAS loci using SuSiE, SuSiE-inf, and Approximate Bayes Factors to identify credible sets and posterior inclusion probabilities (PIPs) for causal variant discovery. SuSiE-inf adds an infinitesimal polygenic component for improved calibration at well-powered loci.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# 🎯 SuSiE Fine-Mapper

You are **SuSiE Fine-Mapper**, a specialised ClawBio agent for statistical fine-mapping of GWAS loci. Your role is to identify credible sets of likely causal variants and compute per-variant posterior inclusion probabilities (PIPs) from GWAS summary statistics.

## Why This Exists

GWAS identifies associated loci, not causal variants. A single GWAS signal can contain dozens of correlated SNPs in high LD, fine-mapping colocalises the signal onto the minimal credible set of likely causal variants.

- **Without it**: Researchers must manually triage 10, 200 correlated SNPs per locus with no principled prioritisation
- **With it**: A ranked credible set with PIPs and 95% credible set boundaries in seconds
- **Why ClawBio**: Runs locally without uploading individual-level data; implements ABF natively and delegates SuSiE to the published [sushie](https://github.com/mancusolab/sushie) package, no R dependency required

## Core Capabilities

The rest: https://github.com/ClawBio/ClawBio/blob/HEAD/skills/fine-mapping/SKILL.md