ClinPGx Database

Overview

ClinPGx (Clinical Pharmacogenomics Database) is a comprehensive resource for clinical pharmacogenomics information, successor to PharmGKB. It consolidates data from PharmGKB, CPIC, and PharmCAT, providing curated information on how genetic variation affects medication response. Access gene-drug pairs, clinical guidelines, allele functions, and drug labels for precision medicine applications.

When to Use This Skill

This skill should be used when:

• Gene-drug interactions: Querying how genetic variants affect drug metabolism, efficacy, or toxicity
• CPIC guidelines: Accessing evidence-based clinical practice guidelines for pharmacogenetics
• Allele information: Retrieving allele function, frequency, and phenotype data
• Drug labels: Exploring FDA and other regulatory pharmacogenomic drug labeling
• Pharmacogenomic annotations: Accessing curated literature on gene-drug-disease relationships
• Clinical decision support: Using PharmDOG tool for phenoconversion and custom genotype interpretation
• Precision medicine: Implementing pharmacogenomic testing in clinical practice
• Drug metabolism: Understanding CYP450 and other pharmacogene functions
• Personalized dosing: Finding genotype-guided dosing recommendations
• Adverse drug reactions: Identifying genetic risk factors for drug toxicity

Installation and Setup

Python API Access

The ClinPGx REST API provides programmatic access to all database resources. Basic setup:

uv pip install requests

API Endpoint

BASE_URL = "https://api.clinpgx.org/v1/"

Rate Limits:

• 2 requests per second maximum
• Excessive requests will result in HTTP 429 (Too Many Requests) response

Authentication: Not required for basic access

Data License: Creative Commons Attribution-ShareAlike 4.0 International License

For substantial API use, notify the ClinPGx team at api@clinpgx.org

Core Capabilities