# Clinpgx Database

Access ClinPGx pharmacogenomics data (successor to PharmGKB).

- Repository: https://github.com/foryourhealth111-pixel/Vibe-Skills (3789 stars)
- Category: Engineering
- License: Unknown
- Last updated: 2026-10-31
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add foryourhealth111-pixel/Vibe-Skills --skill clinpgx-database -g -a claude-code -y`
Codex: `npx skills add foryourhealth111-pixel/Vibe-Skills --skill clinpgx-database -g -a codex -y`
Cursor: `npx skills add foryourhealth111-pixel/Vibe-Skills --skill clinpgx-database -g -a cursor -y`
Gemini CLI: `npx skills add foryourhealth111-pixel/Vibe-Skills --skill clinpgx-database -g -a gemini-cli -y`

## Description

Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided dosing decisions.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# ClinPGx Database

## Overview

ClinPGx (Clinical Pharmacogenomics Database) is a comprehensive resource for clinical pharmacogenomics information, successor to PharmGKB. It consolidates data from PharmGKB, CPIC, and PharmCAT, providing curated information on how genetic variation affects medication response. Access gene-drug pairs, clinical guidelines, allele functions, and drug labels for precision medicine applications.

## When to Use This Skill

This skill should be used when:

- **Gene-drug interactions**: Querying how genetic variants affect drug metabolism, efficacy, or toxicity
- **CPIC guidelines**: Accessing evidence-based clinical practice guidelines for pharmacogenetics
- **Allele information**: Retrieving allele function, frequency, and phenotype data
- **Drug labels**: Exploring FDA and other regulatory pharmacogenomic drug labeling
- **Pharmacogenomic annotations**: Accessing curated literature on gene-drug-disease relationships
- **Clinical decision support**: Using PharmDOG tool for phenoconversion and custom genotype interpretation
- **Precision medicine**: Implementing pharmacogenomic testing in clinical practice
- **Drug metabolism**: Understanding CYP450 and other pharmacogene functions
- **Personalized dosing**: Finding genotype-guided dosing recommendations
- **Adverse drug reactions**: Identifying genetic risk factors for drug toxicity

## Installation and Setup

### Python API Access

The ClinPGx REST API provides programmatic access to all database resources. Basic setup:

```bash
uv pip install requests
```

### API Endpoint

```python
BASE_URL = "https://api.clinpgx.org/v1/"
```

**Rate Limits**:
- 2 requests per second maximum
- Excessive requests will result in HTTP 429 (Too Many Requests) response

**Authentication**: Not required for basic access

**Data License**: Creative Commons Attribution-ShareAlike 4.0 International License

For substantial API use, notify the ClinPGx team at api@clinpgx.org

## Core Capabilities

The rest: https://github.com/foryourhealth111-pixel/Vibe-Skills/blob/HEAD/bundled/skills/clinpgx-database/SKILL.md