Depmap
Retrieves and analyzes Cancer Dependency Map (DepMap) release data, including CRISPR...
Install
npx skills add K-Dense-AI/scientific-agent-skills --skill depmap -g -a claude-code -y- Repository
- K-Dense-AI/scientific-agent-skills55.7k
- Category
- Engineering
- Updated
- 9d ago
- License
- CC-BY-4.0
- Context cost
- Mediumabout 3,000 tokens
- Runs scripts
- Yes, review before use
What it does
Retrieves and analyzes Cancer Dependency Map (DepMap) release data, including CRISPR Chronos gene effects, cancer model annotations, omics biomarkers, and PRISM drug sensitivity. Supports cancer-selective dependency, co-essentiality, and candidate synthetic-lethality analyses with release-aware identifiers and statistical checks.
DepMap, Cancer Dependency Map
When to use
Use this skill to rank dependencies in cancer models, compare prespecified biomarker cohorts, inspect co-essentiality, or relate genetic dependencies to PRISM compound response. These analyses generate target and synthetic-lethality hypotheses; they do not establish clinical efficacy, a therapeutic window, or a causal interaction.
DepMap integrates Broad and Sanger CRISPR screens and hosts independent RNAi and drug-screen datasets. Match each question to its assay and pinned release. RNAi DEMETER2 is a different perturbation modality, not an older CRISPR scoring method.
1. Discover a release, then obtain its files
Use DepMap Downloads and the selected
release's README and release notes. On review, the live catalogue's latest
DepMap Public release was 26Q1, dated 2026-04-01. Rediscover before new work;
a release name or expected quarter is not evidence a release is available.
Verified public endpoint
GET https://depmap.org/portal/api/no-captcha/download/files returns a complete
CSV catalogue, with no request body, API key, or pagination parameters. Required
metadata columns are release, release_date, filename, and md5_hash.
The live response also has url: older files can have links, while recent
release rows have blank links. All 85 entries for 26Q1 had blank url values at
review. Treat availability per row, not per endpoint.
