# Depmap

Retrieves and analyzes Cancer Dependency Map (DepMap) release data, including CRISPR...

- Repository: https://github.com/K-Dense-AI/scientific-agent-skills (55651 stars)
- Category: Engineering
- License: CC-BY-4.0
- Last updated: 2026-10-26
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add K-Dense-AI/scientific-agent-skills --skill depmap -g -a claude-code -y`
Codex: `npx skills add K-Dense-AI/scientific-agent-skills --skill depmap -g -a codex -y`
Cursor: `npx skills add K-Dense-AI/scientific-agent-skills --skill depmap -g -a cursor -y`
Gemini CLI: `npx skills add K-Dense-AI/scientific-agent-skills --skill depmap -g -a gemini-cli -y`

## Description

Retrieves and analyzes Cancer Dependency Map (DepMap) release data, including CRISPR Chronos gene effects, cancer model annotations, omics biomarkers, and PRISM drug sensitivity. Supports cancer-selective dependency, co-essentiality, and candidate synthetic-lethality analyses with release-aware identifiers and statistical checks.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# DepMap, Cancer Dependency Map

## When to use

Use this skill to rank dependencies in cancer models, compare prespecified biomarker
cohorts, inspect co-essentiality, or relate genetic dependencies to PRISM compound
response. These analyses generate target and synthetic-lethality hypotheses; they
do not establish clinical efficacy, a therapeutic window, or a causal interaction.

DepMap integrates Broad and Sanger CRISPR screens and hosts independent RNAi and
drug-screen datasets. Match each question to its assay and pinned release. RNAi
DEMETER2 is a different perturbation modality, not an older CRISPR scoring method.

## 1. Discover a release, then obtain its files

Use [DepMap Downloads](https://depmap.org/portal/data_page/) and the selected
release's README and release notes. On review, the live catalogue's latest
`DepMap Public` release was **26Q1**, dated 2026-04-01. Rediscover before new work;
a release name or expected quarter is not evidence a release is available.

### Verified public endpoint

`GET https://depmap.org/portal/api/no-captcha/download/files` returns a complete
CSV catalogue, with no request body, API key, or pagination parameters. Required
metadata columns are `release`, `release_date`, `filename`, and `md5_hash`.
The live response also has `url`: **older files can have links, while recent
release rows have blank links**. All 85 entries for 26Q1 had blank `url` values at
review. Treat availability per row, not per endpoint.

The rest: https://github.com/K-Dense-AI/scientific-agent-skills/blob/HEAD/skills/depmap/SKILL.md