# Hypothesis Generation

Formulate evidence-bounded scientific questions, candidate hypotheses, rival...

- Repository: https://github.com/K-Dense-AI/claude-scientific-writer (2545 stars)
- Category: Data and ML
- License: MIT
- Last updated: 2026-10-31
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add K-Dense-AI/claude-scientific-writer --skill hypothesis-generation -g -a claude-code -y`
Codex: `npx skills add K-Dense-AI/claude-scientific-writer --skill hypothesis-generation -g -a codex -y`
Cursor: `npx skills add K-Dense-AI/claude-scientific-writer --skill hypothesis-generation -g -a cursor -y`
Gemini CLI: `npx skills add K-Dense-AI/claude-scientific-writer --skill hypothesis-generation -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add K-Dense-AI/claude-scientific-writer`

## Description

Formulate evidence-bounded scientific questions, candidate hypotheses, rival explanations, causal or associational claims, discriminating predictions, measurements, and preregistration-ready analysis plans. Use when turning observations or preliminary findings into transparent, testable research plans without treating hypotheses as facts.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# Scientific Hypothesis Generation

Turn an observation into a transparent set of candidate explanations and tests. A hypothesis is a proposal to be challenged, not a finding, fact, diagnosis, or recommendation.

## Non-negotiable boundaries

Before using unpublished, sensitive, controlled, personal, proprietary, export-controlled, or security-relevant material:

1. Confirm authorization and the applicable institutional, funder, publisher, data-use, privacy, and AI policies.
2. Keep the material local unless an authorized human explicitly approves a named external destination and data scope.
3. Minimize inputs. Do not place sensitive or unpublished data in web searches or external AI systems without authorization.
4. Stop at the appropriate human, animal, biosafety, dual-use, data-governance, or regulatory gate.

Never:

- present a hypothesis, mechanism, causal effect, citation, or apparent pattern as established evidence;
- claim novelty because a quick search found nothing;
- infer causation from association, temporal order alone, predictive accuracy, or model output;
- supply patient-specific diagnosis, treatment, dose, prognosis, or other clinical advice;
- provide harmful experimental optimization or operational detail for pathogens, toxins, weapons, evasion, or other misuse;
- bypass IRB/REC, IACUC, IBC, biosafety, dual-use, privacy, legal, or regulatory review;
- fabricate sources, identifiers, search coverage, data, results, approvals, or preregistration;
- automatically score, rank, select, accept, or reject scientific hypotheses.

If a request crosses a safety gate, produce only a high-level risk/oversight note and route it to the qualified local authority. Do not continue with operational detail.

## Keep the objects distinct

The rest: https://github.com/K-Dense-AI/claude-scientific-writer/blob/HEAD/.claude/skills/hypothesis-generation/SKILL.md