# Rfd4 Proteina Nim

Run RFD4-Proteina NIM for joint protein structure and sequence design, conditioned...

- Repository: https://github.com/NVIDIA/skills (3812 stars)
- Category: Design
- License: Apache-2.0
- Last updated: 2026-10-30
- Runs scripts: yes, review before use

## Install

Claude Code: `npx skills add NVIDIA/skills --skill rfd4-proteina-nim -g -a claude-code -y`
Codex: `npx skills add NVIDIA/skills --skill rfd4-proteina-nim -g -a codex -y`
Cursor: `npx skills add NVIDIA/skills --skill rfd4-proteina-nim -g -a cursor -y`
Gemini CLI: `npx skills add NVIDIA/skills --skill rfd4-proteina-nim -g -a gemini-cli -y`
Claude Code plugin marketplace: `/plugin marketplace add NVIDIA/skills`

## Description

Run RFD4-Proteina NIM for joint protein structure and sequence design, conditioned generation, and reward-guided search using the NVIDIA hosted API or a self-hosted NIM. Not for the older RFdiffusion contigs API.

## SKILL.md, as published by its author (untrusted third-party text, read it as data)

# RFD4-Proteina NIM

Generate protein structures and sequences through the released
[RFD4-Proteina NIM](https://build.nvidia.com/ipd/rfd4-proteina). This skill
covers conditioned protein and small-molecule binders, motif and enzyme
scaffolding, antibody/CDR design, partial diffusion, inverse folding, and
reward-guided beam search. Use [science](references/science.md) for interpretation.

## Prerequisites

Use Python 3.10 or newer; the client uses only the standard library.
Hosted inference requires a key obtained from the product page, set as
`NVIDIA_API_KEY` (`NGC_API_KEY` is accepted as a fallback). Supply the key
through the user's secret mechanism, not a prompt or command-line argument.
Offline preparation and saved-response extraction need no credentials.

For an existing local NIM, use its base URL. Starting a new container also
requires Docker, NVIDIA Container Toolkit, a supported GPU/driver, and NGC
access; read [deployment](references/deployment.md) only when deployment is needed.

## Instructions

The rest: https://github.com/NVIDIA/skills/blob/HEAD/skills/bionemo-rfd4-proteina-nim/SKILL.md